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diagnosis management fungal neurology infections infectiousdiseases betadglucan cns galactomannan laboratory accuracy aids allergy amyotrophic aorta aortic aortoenteric arthritis bandemia biomarkers
Ohle R et al. Clinical Examination for Acute Aortic Dissection: A Systematic Review and Meta-analysis. AEM
Clinical Examination ... Dissection #Aorta #Testing ... Signs #Accuracy #Sensitivity ... #Specificity #SGEM ... VisualAbstract #EBM
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
& Specificity: ... cut-offs defined in clinical ... & Specificity ... BAL GM does not differentiate ... Frozen ice-pops (in setting
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... 96% • Higher specificity ... >90% (In most clinical ... in BAL does not differentiate
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
HIV/AIDS, CGD) Clinical ... Diagnosis and Testing ... Galactomannan sensitivity ... • AspGM can be also ... and low specificity
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
in HIV / AIDS - Differential ... should be based on clinical ... effect/Edema • EBV ... of serum CrAg testing ... comparable to CSF testing
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... especially in the setting ... science/article/abs ... #Bandemia #differential ... CBC #hematology #pathophysiology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
virus • CMV • EBV ... • Common clinical ... and specificity ... /l is regarded as ... and specificity
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
of the clinical ... lateral sclerosis Pathophysiology ... features developing later ... - Further testing ... conditions listed in differential
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
sedimentation rate ... - CCP antibody testing ... has higher specificity ... test but lower sensitivity ... ANA and RF (if clinical
USMLE Epidemiology and Biostatistics Summary Meta-Analysis: pools data from several studies (greater power), limited by quality/bias of
individual studies Clinical ... diseases, describe clinical ... Sensitivity (rule ... Specificity (rule ... alters recall Late-look
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