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diagnosis fungal infectiousdiseases betadglucan galactomannan infections management biomarkers cns comparison differential falsepositives hiv invasive laboratory mycoses neurology opportunistic treatment
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
, Advanced HIV/AIDS ... , CGD) Clinical ... Diagnosis and Testing ... Galactomannan sensitivity ... and low specificity
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... 96% • Higher specificity ... 81% for dx of IA ... >90% (In most clinical
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
& Specificity: ... cut-offs defined in clinical ... & Specificity ... /Spec ~80% for IA ... Frozen ice-pops (in setting
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... should be based on clinical ... effect/Edema • EBV ... of serum CrAg testing ... comparable to CSF testing
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
antigen assay has a sensitivity ... and specificity ... Urinary antigen testing ... yeast • At risk: AIDS ... ASPERGILLOSIS • Aspergillus
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