25 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... Criteria for HLH ... ): Molecular diagnosis ... : • Fever • Splenomegaly ... #hematology #criteria
Fever in Returning Travelers from Tropical Regions - Frequent Differential Diagnoses
Medical History:
 • Skin exposure to
Travelers from ... Frequent Differential Diagnoses ... without localizing signs ... #differential #diagnosis ... #tropical #travel
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Fever of Unknown ... Refer to your ‘Fever ... thin smear • Signs ... values supporting hematologic ... UnknownOrigin #workup #diagnosis
Criteria for Patients Under Investigation for 2019 Novel Coronavirus (2019-nCoV) / COVID-19

Fever or signs/symptoms of lower
Criteria for Patients ... AND A history of travel ... AND A history of travel ... nCoV2019 #COVID19 #Criteria ... #Diagnosis #Wuhan
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... Diagnosis via genetic ... following: • Fever ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... Lymphohistiocytosis #diagnosis ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... - Nonremitting fever ... Histopathologic criteria ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... Symptomatic anemia Diagnosis ... if neutropenic fever ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009

At least three of the following: 
 -
Lymphohistiocytosis (HLH ... ) Diagnostic Criteria ... following: - Fever ... @PulmCrit #HLH ... #Criteria #Hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... - Yamaguchi criteria ... 5 of the below criteria ... #rheumatology # ... management