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differential management dermatology oncology hemophagocytic hlh lymphohistiocytosis systemic algorithm classification erythematosus lupus sle symptoms anemia clinical dermatomyositis disease infections infectiousdiseases
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... thin smear • Signs ... values supporting hematologic ... UnknownOrigin #workup ... #diagnosis
Fever in Returning Travelers from Tropical Regions - Frequent Differential Diagnoses Medical History: • Skin exposure to
Travelers from ... Frequent Differential Diagnoses ... Medical History: • Skin ... without localizing signs ... #differential #diagnosis
Travel History - Clues to Infectious Disease Diagnosis in a Traveler • Where did you
Infectious Disease Diagnosis ... → Leptospirosis ... Schistosomiasis • Skin ... Rabies, cat scratch fever ... Commercial sex worker
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... d-dimer, ↓ NK cell ... ): Molecular diagnosis ... : • Fever • Splenomegaly ... #hematology #criteria
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Physical Exam/Signs ... Hepatomegaly • Skin ... #workup #oncology ... #hematology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
: - Fever >= 39C ... weeks - Typical skin ... with concomitant fever ... #Diagnosis #Major ... #Minor #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... Lymphadenopathy • HSM • Fevers ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
LcSSc) - distal skin ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... disease, recurrent fevers ... (MDS) Most met criteria ... (12%) • giant cell ... Autoinflammatory #Somatic #rheumatology
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