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differential dermatology oncology systemic algorithm antinxp2 antinxp2dm arthritis blastomycosis chronic clinical cll dermatomyositis eosinophil eosinophilia erythematosus gap globulin joint leukemia
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
LcSSc) - distal skin ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Ulcerative Blastomycosis Skin Lesion 57 asymptomatic M from Indiana nonpruritic, painless, progressive skin lesion lower back x
Denies any travel ... an old house & works ... Diagnosis? ... Blastomycosis #SkinRash #dermatology ... #clinical #photo
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... lymphoproliferative disorders ... #workup #oncology ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... arthritis, adult-onset Still ... Non-autoimmune rheumatologic ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Mechanical/degenerative disorders ... noninflammatory Signs ... • Adult onset Still's ... #MSK #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... just beneath the skin ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
But can still have ... chest (in a V-sign ... shoulders (in a shawl sign ... Dermatomyositis #diagnosis ... #management #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gammopathy, and skin ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
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