8 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... #anemia #hematology ... #diagnosis
Algorithm and Differential Diagnosis of Macroscopic Hematuria
Important Historical Elements:
- Painless: suggests malignancy
- Painful: suggests calculi/infection
- Urinalysis:
Algorithm and Differential ... RBC’s, RBC/WBC casts ... intrinsic renal disease ... #EM #IM #Urology ... #Algorithm #Ddxof
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Chorioretinitis • Diagnosis ... toxo IgG • CNS PCR ... Lesions #Brain #differential ... #diagnosis #causes ... #radiology #neurology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... (CVID, WAS), (neurologic ... When do you do a BM ... #Diagnosis #Causes ... #Workup #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
in HIV / AIDS - Differential ... Inferomedial temporal lobes ... Demyelinating disease ... caused by the JC ... effect/Edema • EBV
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... affects the skin, neurologic ... tract, and often causes ... #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
• Heavy chain disease ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver disease ... Gap #ProteinGap #differential ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... statins - probably caused ... #differential #