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rheumatology management differential causes treatment algorithm autoimmune deformity dermatology effusions erythematosus gout hemophagocytic hlh infectiousdiseases knee limp lupus lymphohistiocytosis macrophage
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... MAS #Macrophage #Activation ... #Syndrome #Diagnosis ... #Management #Hematology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
- Differential Diagnosis ... Fever/Chills/Joint ... Acute rheumatic fever ... - Aneurysmal bone ... #msk #physicalexam
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... Hemophagocytosis in bone ... management #treatment #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
skeleton-sacroiliac joint and spine ... causes such as infectious ... antiinflammatory properties e.g ... diagnosis #management ... #Dermatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... abscessus • Line ... Hematologic malignancy ... ) - Bone Marrow
Bone Deformity / Limp - Differential Diagnosis Algorithm Infection • Septic Arthritis • Cortical Hypertrophy •
Bone Deformity / ... Algorithm Infection ... Patellofemoral Syndrome ... Subluxation) Spine ... Deformity #Limp #MSK
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Differential Diagnosis ... fibromyalgia) • Infections ... to: Arthritis, Fever ... Chronic B-cell activation
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
sex • Metabolic syndrome ... 12-24 Hours • Fever ... concomitant infection ... Dual-energy CT → MSU ... overhanging cortical bone
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
- Anasarca - Fever ... vasculitis - Infectious ... fast bacterial infection ... disease, severe fever ... interfollicular zone
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Tenderness → Consider infectious ... Aldolase levels • EMG ... : Fever, joint pain ... forward of the spine ... : • Fever • Interstitial
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