24 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... • XR, MRI to ... #Disease #differential ... #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
g/dl LLN B - Bony ... lesions +1 or ... on MRI studies ... Causes of false- ... MGUS #diagnosis #hematology
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
- Differential ... Peripheral Vascular Disease ... Trauma to Vessel (dislocation ... Vascular #JointPain #MSK ... #Orthopedics #Causes
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Tumours - See Bone ... Lesions Scheme ... Ricketts - Diffuse Pain ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... hemorrhagic skin lesions ... Drug induced - Bone ... #Diagnosis #hematology ... #nonpalpable #dermatology
Focal Periphyseal Edema (FOPE lesion) - MSK Radiology
Imaging Findings:
 • Arrows identifying the characteristic edema-like signal
) - MSK Radiology ... adolescent knee pain ... and bone bridging ... (save $$) Differential ... #clinical #mri
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... burning sensation or pain ... reticularis Differential ... Polyangiitis #GPA #dermatology
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild bone ... Tibial tuberosity pain ... tibial tuberosity Differential ... marrow edema and bony
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
- Differential ... Fever/Chills/Joint pain ... fracture - Patellar dislocation ... - Aneurysmal bone ... diagnosis #msk #
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Pustular skin lesions ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease ... diagnosis #management #Dermatology