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neurology clinical diagnosis video physicalexam differential algorithm management causes syndrome ophthalmology pathophysiology sign pharmacology reflex treatment ocular pediatrics urine comparison
#paracetamol #paracetamoloverdose #NAC
#paracetamol #paracetamoloverdose ... #NAC
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
N-Acetyl Cysteine (NAC ... NAC helps replenish ... Figure 2.1 NAC has ... GSH) precursor, NAC3 ... substitute, and NAC4
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
acetazolamide) Nat-Cl ... symport Na and ... spironolactone) Nat ... +-2CF symport Na ... direct effect) #NaCI
Hypo-osmolar Hypotonic HypoNatremia Algorithm (Serum Na+ < 135 meq/L, serum Osm < 275 mosm/kg) Assess Volume Status,
Algorithm (Serum Na ... Status, Check Urine Na ... Algorithm #Diagnosis #Nephrology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
cotransporter (NCC ... distal tubule. ↑ Nacl ... Pathophysiology #nephrology
Hyponatremia Differential Diagnosis Table • Step 1: Correct for hyperglycemia. Corrected Na = [(glucose - 100)/
Corrected Na = [ ... Urine Osm • Na ... of total body Na ... Diagnosis #Table #nephrology
5-Oxoprolinuria What is it: • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle • Amino acid transport and
Link to chronic paracetamol ... • Continuous paracetamol ... Diagnosis: • HAGMA; Paracetamol ... HDU • Withdraw paracetamol
Restarting Anticoagulation after TIA or Acute Ischemic Stroke • TIA → Consider (re-) starting a NOAC
re-) starting a NOAC ... re-) starting a NOAC ... re-)starting a NOAC ... re-)starting a NOAC ... #Stroke #CVA #neurology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
Enterocolitis (NEC ... • Neutropenia (ANC ... 1min_idconsult #NEC
Fractional Excretion of Sodium - FENa Fractional Excretion of Sodium (FENa) = (Urine Na+ x Serum Cr)
FENa) = (Urine Na ... Serum Cr) / (Serum Na ... Excretion #Sodium #nephrology
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