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hematology oncology management workup abnormal aggregometry algorithm atlas beaus classification clinical cll comparison cvid diseases fingernails hemolytic hypogammaglobulinemia immunodeficiency immunology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... MYH9-Related Disorder ... chain IIA • Thrombocytopenia ... #table #differential ... #diagnosis #hematology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... with qualitative defects ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... • Platelet defects ... - Hemolytic anemia ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... (NSHL) - (most common ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Epidemiology: • Most common ... lymphoproliferative disorders ... • Neutropenia, anemia ... , thrombocytopenia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Most common cytopenia ... Marrow Failure • Chronic ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... • Affects 1:25,000 ... Autoimmunity • Chronic ... specifically immune thrombocytopenia ... autoimmune hemolytic anemia
Nail Pathologies - Findings in or Near Nails Paronychia A superficial infection of the proximal and lateral
Chronic infections ... include diabetes, anemia ... Commonly affects ... heart failure, Hodgkin's ... #Diagnosis #Clinical
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