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hematology oncology hemolytic management algorithm causes classification common comparison cvid extravascular hypogammaglobulinemia immunodeficiency immunology inherited intravascular leukemia lymphocytic lymphoma mds
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... with or without platelet ... #Anemia #Differential ... #workup #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
MYH9-Related Disorder ... structure and cell ... on smear, as well ... #table #differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... lymphoproliferative disorders ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... lymphoproliferative disorders ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... Workup: • Full ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Marrow Failure • Chronic ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to impaired B-cell ... specifically immune thrombocytopenia ... and autoimmune hemolytic ... anemia) • Systemic
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