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hematology oncology hemolytic algorithm causes chronic classification extravascular gap globulin hemolysis inherited intravascular lymphocytic lymphoma management mds myelodysplasia myelodysplastic protein
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... • Neutropenia, anemia ... , thrombocytopenia ... adult T cell leukemia ... #diagnosis #workup
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Syndrome • Defect ... structure and cell ... #Defects #comparison ... #table #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Cell Leukemia ... blood count with differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... lymphoproliferative disorders ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Workup: • Full ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... Thalassemia, Sickle cell ... anemia • Other ... #diagnosis #hematology
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