pathology hemepath differential dermatology table diagnosis disorders platelet thrombocytopenia anemia hodgkins defects workup cell management cll intravascular

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

) (e.g. lupus, CLL ... lymphoproliferative disorders ... Hemoglobinopathies (e.g. sickle cell ... #Causes #differential ... #diagnosis #hematology

Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
• Defect of adhesion due to a lack of GP Ib/IX/V

Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
• Lymphocytes accumulate in large numbers

lymphoproliferative disorders ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology ... #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Consider sickle cell ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #workup #hematology

Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It

• Autoimmune disorders ... Workup: • Full ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate ... #oncology #management

Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly

are a group of disorders ... formed or don’t work ... count (thrombocytopenia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis

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