11 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... granules, and Auer rods ... #APL #APML #Pathology ... #Hematology #Clinical ... #Smear
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytic leukemia ... a bone marrow (BM ... peripheral blood smear ... #Clinical #Path ... BloodSmear #Blood #Smear
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... cells - Blood & BM ... • Cytopenia -> BM ... 50-60 • Auer Rods ... • Peripheral smear
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
linear red "Auer rod ... acute myelogenous leukemia ... #Clinical #Path ... BloodSmear #Blood #Smear ... Microscopy #Auer #Rods
Auer Rods - Bone marrow aspiration revealed 5% blasts and 65% promyelocytes; many promyelocytes had prominent
Auer Rods - Bone ... #Clinical #Path ... #APL #AuerRods # ... AcutePromyelocyticLeukemia #Smear ... #Microscopy #NEJM
Prolymphocytes

In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML).  🔬Tumor
(AML). ... to medium size lymphoid ... Prolymphocytes #Smear ... #Peripheral #Pathology ... #Microscopy #Clinical
Hypersegmented neutrophil in a case of acute myeloid leukemia.

Dysplastic neutrophils are typically hypolobated but can be
acute myeloid leukemia ... #neutrophils #AML ... #Clinical #Hematology ... #Pathology #Smear
B-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Clinical
 - Primarily a disease of childhood, 75% <6 yo
 - Increased
Lymphoblastic Leukemia ... /Lymphoblastic Lymphoma ... Clinical - Primarily ... disease with limited BM ... #pathology #prognosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Immunosuppression (e.g., HIV), EBV ... Autoimmune diseases • Clinical ... involved) • No leukemic ... Noncontiguous spread • Clinical ... Malignancies (eg CML, ALL
Anaplastic large cell lymphoma, ALK+
Clinical
 • First 3 decades of life, M>F
 • Often nodal +
Anaplastic large cell lymphoma ... , ALK+ Clinical ... lungs, liver) • BM ... variant can have leukemic ... ALKPos #hemepath #pathology