34 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... antibodies) • Systemic ... drug-induced SLE) • Systemic ... cases • Sjögren syndrome ... antibodies #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
• Homogeneous: Systemic ... ) • Speckled: Systemic ... SLE), Sjogren's Syndrome ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
central nervous system ... Churg-Strauss syndrome ... disease - systemic ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Inflammatory Conditions: Rheumatologic ... , Vasculitides, ... Kawasaki, Nephrotic syndrome ... #hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Differential Diagnosis Algorithm ... Reactive: - Systemic ... Inflammatory • Systemic ... #Causes #Hematology ... #Oncology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... LAC) • Sjogren Syndrome ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis ... Autoantibodies #Rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Butterfly rash, Vasculitis ... joints Nervous system ... Demyelinating syndromes ... symptoms #diagnosis #rheumatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Differential Diagnosis Algorithm ... Disease Vascular System ... TeIangiectasia Vascular System ... • Steroids • Vasculitis ... #Causes #Hematology