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diagnosis differential treatment symptoms syndrome toxicity toxicology algorithm diabetes diabetic diabeticketoacidosis insulin ketoacidosis nephrology acromegaly anesthesia anesthesiology aniongap aspirin bulimianervosa
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... by an anion gap acidosis ... fatty acid (FA) metabolism ... differential #diagnosis #management ... #endocrinology
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA) DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... of carbohydrate metabolism ... state and fat metabolism ... #Pathophysiology ... #Diabetes #Endocrinology
DKA DIAGNOSTIC CRITERIA: 1. Serum glucose >250 mg/dL 2. Arterial pH <7.3 3. Serum bicarbonate <18 mEq/L 4. At least
significant anion gap metabolic ... acidosis and ketonemia ... Common, early signs ... production, the rate of metabolism ... gap closes and acidosis
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... use in cellular metabolism ... acidosis including ... Toxicology #Diagnosis #Management
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Due to neuronal metabolism ... Signs/Symptoms/Complications ... #pathophysiology ... #endocrinology
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... seems like DKA, ... Labs: Anion-Gap Metabolic ... Acidosis, Respiratory
Euglycemic Diabetic Ketoacidosis (EuDKA) SGLT2 Inhibitors Increasing Indications Significant Adverse Drug Effects Definition of EuDKA • Metabolic acidosis with pH
Definition of EuDKA • Metabolic ... acidosis with pH ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management ... #endocrinology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
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