24 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... also includes symptoms ... of metabolic acidosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... ingestion/exposure Symptoms ... Labs: Anion-Gap Metabolic ... Aspirin #Toxicity #Toxicology
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Renal failure • Metabolic ... acidosis • ARDS ... Colchicine #Toxicity #Toxicology ... #Symptoms #Signs
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Constipation - MSK ... #symptoms #signs
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
post-ingestion) - Symptom ... deterioration Shock and metabolic ... - Anion gap metabolic ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... postpartum): • Initial symptoms ... Monitor and Treat Complications
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Definition of EuDKA • Metabolic ... acidosis with pH ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management
Stages of Iron Toxicity

Iron overdose can cause an anion gap metabolic acidosis. Severe cases can lead
cause an anion gap metabolic ... Recovery from GI symptoms ... Ill Shock and metabolic ... acidosisMetabolic ... Iron #Toxicity #Toxicology
Metabolic Pathways of Toxic Alcohols 

Panel A shows the metabolic pathways of toxic alcohols. Alcohol dehydrogenase
Metabolic Pathways ... Panel A shows the metabolic ... As metabolism proceeds ... ethanol impedes metabolism ... #Metabolism #Pathways
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... PRIS #Diagnosis #Management ... Pharmacology #Toxicity #Toxicology