18 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... spherocytosis, Autoimmune ... hemolytic anemia ... hemolytic anemia ... #differential #diagnosis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... #Hemolytic #Anemia ... #Pathophysiology ... #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential Diagnosis ... inflammation) • Iron ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver ... #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Microcytic - Iron-deficiency ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Volume (<80 fL) • Iron ... • Bleeding • Hemolysis ... Renal Disease, Liver ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... defects, Glutathione metabolism ... elliptocytosis, autoimmune ... #workup #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
deficiencies: Iron ... : Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #diagnosis #calculation
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
malignancies • Anemia ... (specifically: iron ... deficiency, hemolysis ... disorders (e.g. autoimmune ... #Causes #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... RBCs, muscle, liver ... deficiency - Iron ... #differential #diagnosis ... #Laboratory