36 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
alkalosis • Normal ... Hypochloremic metabolic ... Supplement: • Potassium ... #diagnosis #nephrology ... #management #pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... , Gitelman syndrome ... of sodium and potassium ... #Metabolic #Alkalosis ... urine #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... #Primary #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... aldosteronism #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #Nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... Pressure: - Metabolic ... Alkalosis: Emesis ... #differential #potassium ... #nephrology #low
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Low intake • Metabolic ... Renal Losses: • Metabolic ... , Gitelman syndrom ... Algorithm #causes #potassium ... #low #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... thiazide-sensitive site) Metabolic ... • Severe potassium ... after fasting #Metabolic ... Diagnosis #Causes #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... → Hypokalemia Metabolic ... alkalosis - ... #Pathophysiology ... #nephrology #diagnosis
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Transcellular Shift: • Alkalosis ... • Refeeding syndrome ... Diagnosis #Algorithm #nephrology ... #low #potassium
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
Causes of Metabolic ... Alkalosis - Differential ... • Severe potassium ... <2 mmol/L) #Metabolic ... #Alkalosis #Differential