11 results
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
• Brushfield spots ... iris (pigmented spots ... neck • Single ... #PhysicalExam # ... Features #Signs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... white matter, spinal ... Behcet disease) Differential ... diagnosis #management #signs ... #symptoms #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Involving the Skin - Differential ... GPA Cutaneous Single ... Disease • Cogan syndrome ... #dermatology #rheumatology ... #differential #
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Ocular- 50%: Ptosis ... life-threatening Differential ... test - Cogan sign ... - Peek sign ... stimulation - Single
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... ulcers, cutaneous, ocular ... • Cogan Syndrome ... purpura: strong sign ... #diagnosis #rheumatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... anterior chest wall, parts ... skeleton-sacroiliac joint and spine ... sites such as the collar ... #Rheumatology #
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Pinpoint-sized red spots ... with single-lineage ... blood count with differential ... #diagnosis #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... purpura: Strong sign ... : Ocular inflammatory ... #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Malar rash - spares ... Erythematosus #Diagnosis #Rheumatology
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
consciousness Differential ... • Locked-in syndrome ... • Vestibulo-ocular ... • Examine for signs ... caseyalbin #PhysicalExam