87 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... cytokine synthesis - IL ... Basiliximab - IL ... Suppression of IL ... #Pharmacology #Pathophysiology
Nodular pattern
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary TB: random nodules
3. Sarcoidosis: nodules with perilymphatic
Nodular pattern 1. ... Hypersensitivity pneumonitis ... : ill defined centrilobular ... Hypersensitivity pneumonitis
IBD Colonoscopy Surveillance - BSG Guidelines 2019
High Risk - 1 Year
 •  Extensive colitis AND
IBD Colonoscopy ... 2019 High Risk - 1 ... relative with CRC ... relative with CRC ... @drkeithsiau #IBD
Cryptogenic Organizing Pneumonia (COP)

Cryptogenic Organizing Pneumonia Overview:
 • Idiopathic form of organizing pneumonia
 • formerly BOOP
other interstitial pneumonias ... to order: • CBC ... Hypersensitivity pneumonitis ... Treatment: • Mild ... BOOP #pulmonary #ILD
On the left some diseases with a nodular pattern.
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary
nodular pattern. 1. ... Hypersensitivity pneumonitis ... : ill defined centrilobular ... Hypersensitivity pneumonitis ... bronchiolitis: ill
Heme Synthesis Pathway
Enzymes
1. ALA Synthase
2. ALA Dehydratase
3. Porphobilinogen deaminase
4. UP Ill Synthase
5. UP Ill Decarboxylase
6. Coproporphyrinogen
Pathway Enzymes 1. ... UP Ill Synthase ... UP Ill Decarboxylase ... Synthesis #Pathway #pathophysiology
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... insufficiency MECHANISMS: 1. ... cytokines ↓TNF-α, ↓IL ... -6, ↓IL-1 3. ... Hypothermia #sepsis #pathophysiology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
dendritic cell (DC ... activate naive CD4 ... cytokines such as IL ... -5 and IL-1 3, which ... #asthma #pathophysiology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
the disease and ILD ... increases and ILD ... +/CD8+ ratio are ... prevalence of RP-ILD ... Phenotype 1
Fig. 1 Pathophysiology of septic myocardial dysfunction. IL interleukin, iNOS induced nitric oxide synthase, PMN polymorphonuclear
Fig. 1 Pathophysiology ... IL interleukin, ... necrosis factor #Pathophysiology