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dermatomyositis hematology activation amiodarone antimda5dm antinxp2 antinxp2dm calcium common cppd cvid deposition disease erythematosus forearm fracture hypogammaglobulinemia immunodeficiency immunology induced
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
anti-NXP2 Abs Lung ... Phenotype 1 ... #AntiMDA5 #Dermatomyositis ... #rheumatology # ... dermatology #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... -1 and IL-6, leading ... rash) • Heart, lung ... #Diagnosis #Management ... #Hematology #Rheumatology
Monteggia Fracture Fracture of proximal ulnar shaft with radial head dislocation. Remember “MUGR” to recall where
), compartment syndrome ... if types I or Ill ... followup within 1 ... Radiology #XRay #Diagnosis ... #Proximal #MSK
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... and 1:50,000 patients ... • Chronic lung ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... -1 inhibitors, IL ... #Rheumatology # ... diagnosis #management ... #Dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... #Rheumatology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
Amiodarone Induced Lung ... respiratory distress syndrome ... including: 1. ... Exclusion of other ILDs ... #management #Toxicology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Interstitial Pneumonitis ... phenomenon (16%) MSK ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Non-small-cell lung ... was diagnosed in ... Prednisone at 1 ... #management #rheumatology ... #dermatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
trauma (> 65 years old ... disease states 1. ... Crowned Dens Syndrome ... Deposition #Disease #Rheumatology ... #diagnosis #management
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