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diagnosis dermatomyositis product reactions activation anemia antimda5 antimda5dm antinxp2 antinxp2dm aplastic calcium common cppd cvid deposition disease erythematosus hemeonc hemophagocytic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... -1 and IL-6, leading ... rash) • Heart, lung ... #Diagnosis #Management ... #Hematology #Rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
onset [33-74%] • Blood ... anti-NXP2 Abs Lung ... Phenotype 1 ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... and 1:50,000 patients ... • Chronic lung ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... -1 inhibitors, IL ... #Rheumatology # ... diagnosis #management ... #Dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... Erythematosus #Diagnosis #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
F • 3 peaks: 1) ... Constitutional Syndromes ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Interstitial Pneumonitis ... phenomenon (16%) MSK ... MALT Lymphoma • Lung ... #Rheumatology # ... Diagnosis #Management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Related Acute Lung ... 100,000,000, HCV 1 ... 2,000,000, HTLV 1 ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Related Acute Lung ... 100,000,000, HCV 1 ... 2,000,000, HTLV 1 ... Transfusion #diagnosis #management ... #hematology #reactions
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Non-small-cell lung ... Prednisone at 1 ... Dermatomyositis #diagnosis #management ... #rheumatology # ... dermatology
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