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diagnosis management comparison differential rheumatology summary treatment anemia arthritis chagas children coronavirus covid19 druginduced hematology hemophagocytic hivaids hlh hospitalization infections
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
lymphoid interstitial pneumonitis ... in particular) Evaluation ... Infectious Diseases ... Infections #HIVAIDS #workup ... #diagnosis #evaluation
Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease CDC Case Definition for MIS-C; • < 21
Kawasaki Disease ... CDC Case Definition ... • < 21 years old ... other reasons for disease ... diagnosis #peds #pediatrics
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
necrosis, Lyme disease ... viral arthritis Workup ... count, and crystal evaluation ... 90% sensitive in pediatrics ... MH/CCF/CWRU EM
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... hallmark for the disease ... decrease in most cases ... hematuria (without casts ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... cytokines (TNFa,lL1, IL6 ... • Autoimmune diseases ... Drugs, Unknown cause ... inhibitors under evaluation
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Prognosis: Usually mild ... Discontinuation of causal ... • Immunologic Workup ... : Chronic disease
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
caused by the protozoan ... asymptomatic or mild ... only available at CDC ... q12h)x60 days • Pediatric ... 90-120 days • Pediatric
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
phlebotomy/ blood work ... depletion in acutely ill ... during clinical evaluations ... prolonged rest can cause ... Anemia of renal disease
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