5 results
diagnosis hlh lymphohistiocytosis clarksons leak macrophage mas polychondritis relapsing summary timeline
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... A subset of hemophagocytic ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... • Clinical: fever ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... age, however the disease ... following: • Fever ... #treatment #hematology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
- Capillary leak ... syndrome Epidemiology ... #Capillary #leak ... #management #timeline ... #treatment #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... Sarcoidosis • Behcet disease ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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