16 results
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
calcification of both adrenal ... confirmed the diagnosis ... and gut, which causes ... #clincial #peds ... #infant #NEJM #
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... solid cancers • Autoimmune ... Drugs, Unknown cause ... treatment #summary #rheumatology
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... (COVID19, CMV/EBV ... immobility • Critical ... myopathy - Autoimmune ... #differential #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... histopathologic term ... by neutrophilic autoimmune ... periumbilical region), nausea ... Pathophysiology #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... disease • Non-autoimmune ... rheumatologic diseases ... #Rheumatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
/Sepsis/Shock, Autoimmune ... Immunosuppressive agents, Renal ... the underlying cause ... Seizures: Treat with AEDs ... until cause identified
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... mucositis - Rash ... #rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... Sjogrens #Syndrome #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Immunosuppression • Autoimmune ... Hodgkin Lymphoma - Clinical ... lymph node biopsy (diagnostic ... Hodgkins #lymphoma #diagnosis
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
sawtooth rete pegs ... confirming the diagnosis ... thought to be an autoimmune ... #NEJM #clinical ... lichen #planus #derm