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differential vasculitis ck classification clinical creatine elevated erythematosus gap globulin hematology kinase lichen lupus management myopathy photo planus protein proteingap
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... (COVID19, CMV/EBV ... myopathy - Autoimmune ... Inclusion body myositis ... #differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... Conjunctivitis, mucositis ... - Rash, arthritis ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... neuropathy, transverse myelitis ... Sjogrens #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... pulmonary and renal ... • Rash, arthritis ... tract, and often causes ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #rheumatology #
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
confirming the diagnosis ... Although the cause ... thought to be an autoimmune ... #NEJM #clinical ... lichen #planus #derm
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... cancers, HCC, renal ... #differential #diagnosis ... #hematology
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