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differential dermatology infant management vasculitis antinxp2 antinxp2dm calcifications classification clincial clinical compared comparison dermatomyositis endocrinology erythemas evaluation examination gap globulin
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
glands. ... confirmed the diagnosis ... and gut, which causes ... #clincial #peds ... #infant #NEJM #
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... malignancies, autoimmune ... variant of lichen planus ... infection and autoimmune ... #differential #diagnosis
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
sawtooth rete pegs ... confirming the diagnosis ... thought to be an autoimmune ... #NEJM #clinical ... #derm #wickhams
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
aldosterone - Low in cases ... confirmation of autoimmune-mediated ... atrophied from a long-term ... glands as a result ... Evaluation #laboratory #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... salivary and lacrimal glands ... Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... mucositis - Rash ... #rheumatology #
Newborn Infant - Routine Examination Birthweight, gestational age and birthweight percentile are noted. General observation Of the baby's
When the diagnosis ... 160 beats/min in term ... intra-abdominal masses ... #Examination #Peds ... #Pediatrics #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... pulmonary and renal ... , mucositis • Rash ... tract, and often causes ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... cancers, HCC, renal ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... Myositis #Myopathy #rheumatology
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