9 results
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
confirmed the diagnosis ... deficiency, or Wolman’s disease ... and gut, which causes ... #clincial #peds ... #infant #NEJM #
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
confirming the diagnosis ... an autoimmune disease ... used in primary treatment ... #NEJM #clinical ... #derm #wickhams
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... Clinical history ... pancreas, biliary, renal ... aorta, salivary glands ... supporting long-term
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Posterior Reversible Encephalopathy ... Shock, Autoimmune disease ... the underlying cause ... • Treatment of ... until cause identified
Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 • Direct lesion contact during sex is responsible
Syphilis - Clinical ... responsible for most cases ... loss • Skin: Rash ... meningovascular disease ... Syphilis #stages #diagnosis
Acute Retroviral Syndrome
Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection

 •
Fever (75%) • Encephalopathy ... (28%) • Skin rash ... Epstein-Barr virus (EBV ... antibody test) Treatment ... ART to slow HIV disease
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
should be based on clinical ... Antimicrobial treatment ... Demyelinating disease ... caused by the JC ... effect/Edema • EBV
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
salivary and lacrimal glands ... Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... Adenocarcinoma Treatment
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
Violaceous papules or plaques ... auricular papules Clinical ... Muscle atrophy may cause ... had more severe disease ... positive patients Treatment