10 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Maculopapular rash ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
of fibrin split products ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... and petechiae Causes ... Constitutional Syndromes ... Anemia #oncology #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... infections with skin ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... infections with skin ... diagnosis #management #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... glomerulonephritis) • Anti-GBM ... mucositis - Rash ... • Cogan Syndrome ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, mucositis • Rash ... tract, and often causes ... pain and GN Anti-GBM ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
gammopathy, and skin ... changes (POEMS syndrome ... acute HIV, HBV, EBV ... gastric tumors • Hematology ... differential #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused