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diagnosis hematology bruising classification erythematosus hemeonc hemophagocytic hlh idiopathic lymphocytopenia lymphohistiocytosis lymphopenia management myopathy myositis purpura sle systemic thrombocytopenia vasculitides
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
• Autoimmune ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... #Differential # ... Causes #lymphocytopenia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... La, anti-Jo-1, SCL
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... SLE (systemic lupus ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... mucositis - Rash ... such as systemic lupus ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Infections (e.g., EBV ... Malignancies ▪ Autoimmune ... of NK cells and CD8 ... Infections, malignancy, autoimmune
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