32 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • XR, MRI to ... #Joint #Pain #SickleCell ... #Disease #differential ... #diagnosis #causes
Chronic Joint Pain - Differential Diagnosis Algorithm 
Intra-Articular
 - Bone
     • Stress
Chronic Joint Pain ... - Differential ... Diagnosis Algorithm ... Osgood-Schlatter Disease ... #Orthopedics #Causes
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... ), RA, crystal disease ... #Joint #Pain #MSK ... rheumatology #approach #workup ... #differential #
Aortitis - Diagnosis and Workup
Clinical History:
 - Fever, weight loss, deterioration of general health
 - Aortic
regurgitation - Pain ... hypertension) - Symptoms ... Inflammatory diseases ... Nivolumab, GM-CSF ... #Workup #Differential
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... of Joint Disease ... #approach #workup ... #differential # ... diagnosis #arthritis
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... extrapulmonary cases ... of bacilli to bone ... /joints via hematogenous ... : - MRI is modality
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
syndrome is a rare chronic ... • Bone and joint ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Differential Diagnosis ... noninflammatory Signs ... constitutional symptoms ... weeks) Can Be Caused ... #pain #Differential
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... -> chronic pain ... Malnutrition • Wilson's disease ... mineralization Symptoms ... Phosphatase: • Other causes
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... abnormal pressure on joints ... Heart Failure (CHF ... pathophysiology #diagnosis ... #signs #symptoms