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hematology differential alp leukemia management phosphatase aplastic chronic classification cll disorders elevation hemolysis hemolytic hodgkins hyophosphatasia low lymphocytic lymphoma mds
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... hyperplasia of bone ... Hemolysis #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Algorithm ALP ... Intestine - Other causes ... symptoms - Pain ... #Algorithm #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... • Pernicious anemia ... mineralization Symptoms ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
pylori test (GI symptoms ... changes), high MCV anemia ... candidate) - Bone ... #Causes #Workup ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... and petechiae Causes ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Anemia • Bone ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... -> AML: Blast crises ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... Warm AIHA • Bone ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... ingestion • B symptoms ... Hodgkin Lymphoma Workup ... anymore • Routine bone ... #oncology #management
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