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differential dermatology arthritis dermatomyositis leukemia management msk pain symptoms systemic vasculitis algorithm antimda5 antimda5dm antinxp2 antinxp2dm approach autoimmune chronic classification
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... Like in this case ... Chronic = RA, SLE ... #rheumatology # ... approach #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
thickening Signs ... Musculoskeletal: joint ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Sjögrens (15%) Skin ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... noninflammatory Signs ... weeks) Can Be Caused ... arthritis • SLE ... #MSK #rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
inflammation of the joints ... Episcleritis Signs ... and pain of the joints ... Causes: - Idiopathic ... #dermatology #oncology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... interphalangeal joints ... ulcerations • Skin ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... Hepatomegaly • Skin ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... bone pain, fever, joint ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... vesicular eruption - Joints ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #
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