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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Erythematosus ... #Erythematosus ... #SLE #hematology ... #differential #diagnosis
Subacute Cutaneous Lupus erythematosus (SCLE): Erythematous, warm, plaques in light exposed distribution (also on patient's neck),
Subacute Cutaneous Lupus ... SCLE): Erythematous ... Subacute Cutaneous Lupus ... Images #Clinical #Dermatology ... #SCLE #Photo #UCSDH
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... heart failure • Diabetes ... Systemic #Secondary #dermatology ... #Differential #Diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Vesicopustule on erythematous ... lesions • Discoid lupus ... erythematosus ... #dermatology ... #differential #diagnosis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
- Differential Diagnosis ... Bullous systemic lupus ... erythematous ... tarda • Diabetic ... Vesiculobullous #SkinRash #dermatology
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
- Differential Diagnosis ... Disease: Discoid lupus ... erythematosus, ... erythematosus, ... #dermatology #Hairloss
Nail fold Changes in Dermatomyositis

Nail folds can be helpful as well. There are a variety of
Nail fold Changes ... found in CTDs (LE ... RashDecisionz #Fingernails ... Dermatomyositis #Dermatology ... #Clinical #Photo
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
erythematosus ... SJIA], systemic lupus ... erythematosus [ ... SLE], AOSD) • Infection ... Activation #Syndrome #Diagnosis
Common Dermatological Conditions - Distribution and Morphology
 • Acne vulgaris - Face, upper back, chest -
closed comedones, erythematous ... scalp, lower back, fingernails ... silvery scale; nails ... ; pruritis #dermatology ... #differential #diagnosis
Terry's Nails

Patient of about 70 years, HIV positive, transplanted kidney donor cadaver in the previous 6
Terry's Nails ... are seen (see image ... renal failure, diabetes ... Fingernails #Hands ... PhysicalExam #Clinical #Photo