23 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... bcr-able (+) ↑ WBC ... Blood #Disorders #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... iron deficiency anemia ... #Morphology #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... cells - Sickle cell ... key #diagnosis #differential ... #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... Neutrophil (Normal) Differential ... #differential # ... #CBC #hematology ... #pathophysiology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
transform into a RBC ... , Intrinsic RBC ... defects (e.g. sickle cell ... Production #Index #hematology ... #anemia #differential
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... uw_IMresidency #CLL ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell ... anemia, Thalassemias ... #Hemolysis #Differential ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Cr >2 mg/dL or CC ... 40 ml/min A - Anemia ... diseases, CML, ... MGUS #diagnosis #hematology ... #oncology