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differential symptoms lupus management systemic erythematosus testing vasculitis anemia autoantibodies behcet chronic classification cll comparison disease disorders druginduced eosinophil eosinophilia
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
thickening Signs ... Raynaud's, digital ulcers ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Nephropathy 16% - Oral ulcers ... Neurological 12% - Thrombocytopenia ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Venous disease (SVC ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs ... #symptoms #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
5-10d, venous (DVT ... arterial thrombosis, skin ... Confirmatory test ↑Se ... exposure (prevent skin ... #Treatment #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... genotypes): SS, SC, SE ... Schistocytes, thrombocytopenia ... #Algorithm #workup ... #hematology #testing
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Alopecia, oral ulcers ... #comparison #table ... #rheumatology # ... diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... plaques, nodules, ulcers ... #workup #oncology ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
livedo reticularis, ulcers ... genital aphthous ulcers ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #
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