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management peds antibiotics febrile hemophagocytic lp lymphohistiocytosis risk stepbystep stratification disease ebm hematology incomplete kawasaki summary
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... following: • Fever ... • Bicytopenia Treatment ... #management #treatment ... #hematology
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... “low risk” an infant ... with fever without ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Unknown cause Treatment ... Nicolas Taar ... #management #treatment ... #summary #rheumatology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... EBM #Management #Pediatrics ... Stratification #Fever
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Infants ≤6 months ... old on day ≥7 of fever ... echo is positive, treatment ... #Diagnosis #Peds ... #Pediatrics #Kawasaki
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