12 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
in diminished muscle ... Respiratory muscles ... myasthenia Diagnosis ... immunologic assay - MuSK ... #diagnosis #management
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... , Myasthenia Gravis ... aminoglycosides) • Muscles ... #differential #diagnosis
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
and Management ... Prevalence: 1-2 cases ... Pathophysiology ... autoantibodies - TPO, TTG ... #Management #treatment
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Fairly symmetric muscle ... Guillain-Barre Diagnosis ... #diagnosis #management
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... but 5% have anti—muscle-specific ... More likely to cause ... #Myasthenia #Gravis ... #diagnosis #management
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
- Differential Diagnosis ... and Management ... Dermatomyositis) AKI - Pathophysiology ... fluid into injured muscles ... #causes #treatment
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... and Management ... survival is 93-95% Pathophysiology ... anterior/posterior MSK ... #Management #Signs
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
- Differential Diagnosis ... Manifestations Causes ... rice/processed grains ... extremities - Muscle ... #nutrition #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... and Management ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Sanguinis, Mitis, Oralis ... Septic Emboli Cause ... Treat underlying cause ... gallolyticus, clostridium ... #management #cardiology