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diagnosis clinical neurology ultrasound differential treatment thigh myositis sonostuff syndrome transverse barre clostridial clostridium deltoid guillain myasthenia myonecrosis nutrition ossificans
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
in diminished muscle ... Respiratory muscles ... : “myasthenic crises ... immunologic assay - MuSK ... #diagnosis #management
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... Syndrome, Myasthenia Gravis ... aminoglycosides) • Muscles ... Neuromuscular #Weakness #Causes
Hypophosphatemia and Hypoxia - Pathophysiology ↓ Phosphate leads to ↓ red cell 2,3-DPG and a reduction
and Hypoxia - Pathophysiology ... reduction in ATP ... pathway away from ATP ... Phosphate is a cause ... respiratory #hypoxia #pathophysiology
Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
of Myasthenia Gravis ... Corticosteroids (may cause ... Patients with MuSK-MG ... acetylcholinereceptor #muscle-specificreceptortyrosinekinase ... #AChR #MuSK #VC
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... Person Syndrome Pathophysiology ... autoantibodies - TPO, TTG ... SPS #Diagnosis #Management
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... but 5% have anti—muscle-specific ... More likely to cause ... #Myasthenia #Gravis ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... • TMA’s (HUS/TTP ... Schistocytes - MAHA: TTP ... Treat primary cause ... #treatment #management
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause ... periodontitis • ITP
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Fairly symmetric muscle ... • Respiratory Muscle ... Syndrome #diagnosis #management
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Causes progressive ... , muscle atrophy ... Escorial criteria uses ... neurology #diagnosis #management
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