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diagnosis neurology treatment differential barre guillain myasthenia nutrition ascorbicacid beriberi deficiency gbs guillainbarre korsakoff manifestations neuromuscular person rhabdomyolysis sarcoidosis scurvy
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
in diminished muscle ... Respiratory muscles ... : “myasthenic crises ... immunologic assay - MuSK ... #diagnosis #management
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... Guillain-Barre syndrome ... , Myasthenia Gravis ... aminoglycosides) • Muscles
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... Pathophysiology ... autoantibodies - TPO, TTG ... SPS #Diagnosis #Management
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Fairly symmetric muscle ... • Respiratory Muscle ... #diagnosis #management
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... but 5% have anti—muscle-specific ... More likely to cause ... #Myasthenia #Gravis ... #diagnosis #management
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... iniury, Compartment syndrome ... Dermatomyositis) AKI - Pathophysiology ... fluid into injured muscles ... #Summary #causes
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... symptoms are not caused ... anterior/posterior MSK ... Sarcoidosis #Diagnosis #Management
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations Causes of Thiamine Deficiency: • Poor intake: - Diets
Manifestations Causes ... rice/processed grains ... - Refeeding syndrome ... extremities - Muscle ... beriberi #nutrition #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause ... periodontitis • ITP
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... fairly symmetric muscle ... the underlying pathophysiology ... #diagnosis #management
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