Symptoms Distinguishing Groups of Cutaneous Drug Reactions IgE-mediated reactions: • Onset minutes to hours into treatment course • Raised off of the skin • Pruritic • Each lesion lasts <24h • Fades without scarring Benign T-cell-mediated reactions: • Onset days into treatment course • Typically less pruritic than lgE-mediated reactions • Each lesion lasts > 24h • Fine desquamation with resolution over days to weeks Severe T-cell-mediated reactions or severe cutaneous adverse reactions • Onset days to weeks into treatment course • Blistering and/or skin desquamation • Mucosal and/or Organ involvement • Usually requires hospitalization #Cutaneous #Drug #Reactions #dermatology #clinical #comparison #classification
