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Causes of Hypernatremia - Differential Diagnosis Inadequate water intake: • Lack of access to water Extrarenal hypotonic fluid loss: • GI losses or perspiration Renal concentrating defect: • Diuretics • Osmotic diuresis • Central diabetes insipidus • Nephrogenic diabetes insipidus Excessive salt intake: • Hypertonic fluid administration #Hypernatremia #Differential #Diagnosis #Causes #nephrology #sodium #high