Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
• EM appears 7-14 days at the site of Ixodes bite
• Fatigue, myalgia, arthralgia, headache, fever (not common)
• Laboratory abnormalities are rare and mild
Stage 2. Disseminated
• Several days-weeks after EM
• Heralded by neurologic SSX (lymphocytic meningitis, CN palsies, radiculopathy, PN)
• Cardiac SSX (AV block)
• Months to several years after
• Arthritis
- Large joints (knees), 1-2 joints
- Remitting, chronic
• Neurologic
- Cognitive impairment
- Normal CSF
- CSF + Lyme antibodies
WuidQ: Washington University ID Questions @WuidQ
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