Pharmacologic Options for Hypercalcemia Associated with Cancer Rehydration with NS followed by loop diuretics • IV normal saline - Enhances GFR and renal excretion of Ca2+ • Furosemide - Inhibits Ca2+ resorption in the renal tube First-line medications: intravenous bisphosphonate • Pamidronate, Zoledronic acid - Inhibits osteoclast activity; decreases bone resorption • Denosumab - Inhibits RANKL to decrease osteoclast activity Second-line medications • Glucocorticoids - Inhibits vitamin D conversion to calcitriol • Calcitonin - Inhibits bone resorption • Gallium nitrate - Inhibits osteoclast activity #hypercalcemia #medications #management #drugs #treatment #pharmacology #table
