Restrictive Cardiomyopathy - Diagnosis and Causes Clinical: Dyspnea, Exercise Intolerance, ↑ "Right Sided-Symptoms" (ascites, hepatomegaly, ↑↑peripheral edema) Physical Exam: ↑JVP, Prominent X and Y Descents, Rales,+S4, MR and TR Murmurs Imaging: Echocardiography, Cardiac MRI, Cardiac Catheterization Etiology of Restrictive Cardiomyopathy • Infiltrative: Amyloidosis (AL Amyloid, Wild Type TTR, Senile TTR), Sarcoidosis, Primary Hyperoxaluria • Storage: Hemochromatosis, Fabry's Disease, Nieman-Pick Disease, Danon Disease, Gaucher Disease, Other Glycogen Storage Disease, Mucopolysaccharidosis Type I and II • Endomyocardial: Carcinoid Heart Disease, Cancer-Related (i.e., Radiation, Chemotherapy, Metastases), Endomyocardial Fibrosis, Hyper-eosinophilc Syndrome, Endocardial Fibroelastosis, Idiopathic (i.e., Drug-Related) • Non-lnfiltrative: Idiopathic, Diabetic Cardiomyopathy, Systemic Sclerosis, Myofibrillar Myopathies, Sarcomeric Protein Disorders (i.e., TNN13, TNNT2, MYH7, MYBPC3), Radiation Carditis - Cardionerds - Karan Desai MD, MPH @karanpdesai #Restrictive #Cardiomyopathy #Diagnosis #Causes #differential #cardiology #algorithm
