Sickle Cell Disease (SCD) Nephropathy
• Cortical Manifestations
- Main issue: Hemolysis-associated endothelial dysfunction
• Early alterations
• Late alterations
- Proteinuria
- Glomerular pathology
- CKD/ESKD
• Medullary Manifestations
- Hematuria
- Papillary Necrosis
• Tubular Manifestations
- Supranormal proximal tubular
- Impaired concentrating ability with resultant isosthenuria
- Impaired K secretion
- Incomplete RTA
- Nasim Wiegley, MD @NWiegley
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