Acute Pain Control In Patients On Medication Assisted Treatment (MAT) Methadone - µ-opioid receptor agonist: 1) Continue maintenance dose 2) Try non-opioid analgesics 3) Try increase dose or frequency of dosing - go slowly given long half-life 4) Add short-acting opioids Buprenorphine - Partial µ-opioid receptor agonist 1) Continue maintenance dose 2) Try non-opioid analgesics 3) Try increase dose or frequency of dosing 4) Add PRN doses of buprenorphine 5) Add short-acting opioids Naltrexone - µ-opioid receptor Acute pain control can be challenging as naltrexone has high binding affinity for the µ-opioid receptor 1) Try non-opioid analgesics 2) Add high-potency opioids 3) Try regional nerve blocks by Alyssa Mancini, MD @AlyssaManciniMD via @iMedEducation #MAT #PainControl #management #Buprenorphine #methadone #addiction #opiate
