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RPR - False Positives Causes of a false positive RPR that are not syphilis. (False-negative treponemal tests are rare; case reports have described atypical serologic responses to syphilis in some patients living with HIV). Acute (<6 months): • Spirochete Infections • Acute Infections • Immunizations Chronic (>6 months): • Chronic Infection • Autoimmune Disorders • Other Conditions #RPR #False #Positives #differential #diagnosis #syphilis #laboratory