GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1 = Glucagon-like peptide 1; normally produced by the gut) Examples: • Exenatide (Byetta) - Twice/day or weekly injection (ER version) • Liraglutide (Saxenda, Victoza) - Daily injection • Dulaglutide (Trulicity) - Weekly injection • Semaglutide - Weekly injection (Ozempic), or daily tablet (Rybelsus) Major Advantages: • Weight loss (~1.5-2.5kg) • Liraglutide, dulaglutide, and semaglutide variety of adverse CV outcomes in high risk patients with T2D + atherosclerotic heart disease Contraindications: • Personal or family history of medullary thyroid cancer • Personal history of pancreatitis Common Side Effects and Toxicities: • Gl side effects (e.g. diarrhea, nausea, worsen preexisting gastroparesis?) • Association with pancreatitis (though not definitively cause/effect) • May ↑ risk of medullary thyroid cancer - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #GLP1 #Receptor #Agonists #Pharmacology #Summary #DM2 #diabetes #endocrinology
